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Duo Fusion

Duo Fusion & Zinc

Depletes Zinc. This medication is commonly used for Stomach Acid

Why Duo Fusion affects Zinc

Long-term use of H2 blockers may increase your risk of zinc deficiency. These medications work by reducing stomach acid, which is crucial for absorbing zinc from food. Zinc is an essential mineral that supports a healthy immune system and wound healing. Deficiency can lead to various health problems. A study directly investigated the impact of cimetidine, a common H2 blocker, on zinc absorption. The research found that zinc absorption significantly decreased after cimetidine administration, highlighting the role of stomach acid in this process. Individuals who take H2 blockers for extended periods should consider supplementation with zinc to protect against a deficiency.

Clinical Evidence

Sturniolo GC, Montino MC, Rossetto L, Martin A, D'Inca R, D'Odorico A, Naccarato R. Inhibition of gastric acid secretion reduces zinc absorption in man. J Am Coll Nutr. 1991 Aug;10(4):372-5. Sa'adah MA, Al Salem M, Ali AS, Araj G, Zuriqat M. Cimetidine-associated optic neuropathy. Eur Neurol. 1999 Jul;42(1):23-6. Chao HC. Zinc Deficiency and Therapeutic Value of Zinc Supplementation in Pediatric Gastrointestinal Diseases. Nutrients. 2023 Sep 22;15(19):4093.

Recommended Replacement

Zinc Bisglycinate12.5 mg

Related Health Impacts

  • Age-Related Vision Loss

    Low zinc status has been linked to a higher risk and faster progression of age-related macular degeneration (AMD), in part because zinc is concentrated in the retina and supports antioxidant defenses there. In the landmark AREDS trial, a supplement formula containing zinc (80 mg as zinc oxide), along with antioxidants, reduced the risk of progression to advanced AMD by about 25% in people with intermediate disease or advanced disease in one eye over roughly 5 years. Other research has shown that inadequate zinc intake is more common in older adults with AMD, reinforcing the idea that maintaining healthy zinc levels may be an important, and often overlooked, strategy for preserving macular health with age.

Supplement Recommendation

Zinc Bisglycinate by Pure Encapsulations15 mg

Other Nutrients Affected by Duo Fusion

Next Steps
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