Depletes Magnesium. This medication is commonly used for Inflammation
Corticosteroids can increase the body's excretion of magnesium, potentially leading to a deficiency. This is concerning because magnesium plays a vital role in many bodily functions, including muscle and nerve function. Research suggests that magnesium supplementation alleviated corticosteroid therapy associated muscle atrophy. Supplementation with magnesium should be considered during long term corticosteroid therapy.
Schutten JC, Joris PJ, Minović I, Post A, van Beek AP, de Borst MH, Mensink RP, Bakker SJL. Long-term magnesium supplementation improves glucocorticoid metabolism: A post-hoc analysis of an intervention trial. Clin Endocrinol (Oxf). 2021 Feb;94(2):150-157.Zheng L, Huang L, Chen Z, Cui C, Zhang R, Qin L. Magnesium supplementation alleviates corticosteroid-associated muscle atrophy in rats. Eur J Nutr. 2021 Dec;60(8):4379-4392. McKay LI, Cidlowski JA. Physiologic and Pharmacologic Effects of Corticosteroids. In: Kufe DW, Pollock RE, Weichselbaum RR, et al., editors. Holland-Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker; 2003.
Magnesium Citrate — 75 mg
Low or depleted magnesium levels are associated with a higher likelihood of several cardiovascular problems, including arrhythmias, where people with low magnesium have been shown to have 2–4 times higher odds of these rhythm disturbances compared with those with normal levels. Low magnesium is also linked to worsening coronary artery disease, progression of heart failure, and development or aggravation of hypertension, driven by disrupted cardiac electrical stability, vascular function, and electrolyte balance. Even mild magnesium depletion may contribute to higher blood pressure over time, adding to the overall cardiovascular burden, especially in individuals with existing heart disease or multiple risk factors.
Low or depleted magnesium levels place people with diabetes and metabolic syndrome (MetSyn) at higher risk of worsening glycemic control and insulin resistance because magnesium is essential for normal glucose metabolism and beta-cell function. When magnesium is low, these metabolic pathways become less efficient, amplifying blood sugar instability, lipid abnormalities, and other MetSyn features. Even moderate depletion can accelerate type 2 diabetes and MetSyn-related complications, underscoring the need for monitoring magnesium status in these vulnerable groups.
Magnesium (as Magnesium Citrate) by Pure Encapsulations — 150 mg