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Codeine + Aspirin
Depletes
Prolonged use of Codeine + Aspirin can impact 3 essential nutrients.
Vitamin C
Regular use of aspirin (acetylsalicylic acid) can increase how much vitamin C your body gets rid of through urine, potentially leading to deficiency. If you take aspirin regularly, consider supplementing with vitamin C supplementation.
Replace with Vitamin C Ascorbic Acid (200 mg)
Research: Vitamin B6 (50% Pyridoxine HCL, 50% P-5-P)
Vitamin B12
Research found that individuals hospitalized with heart disease and a history of aspirin use were nearly twice as likely to have low or borderline vitamin B12 levels compared to non-aspirin users. While this doesn't definitively prove aspirin causes B12 deficiency, it raises a potential link. Aspirin can irritate the stomach lining in some individuals. This is concerning because the stomach plays a crucial role in vitamin B12 absorption by producing hydrochloric acid and intrinsic factor. Both are essential for proper B12 uptake.
Replace with Vitamin B12 Methylcobalamin (0.2 mg)
Research: van Oijen MG, Laheij RJ, Peters WH, Jansen JB, Verheugt FW; BACH study. Association of aspirin use with vitamin B12...
Also Benefits From:
Omega 3
Omega-3 fatty acids offer promise for managing pain associated with osteoarthritis (OA). Research suggests they may work by reducing inflammation, a key contributor to OA pain and stiffness. Studies involving over 2000 patients with OA showed that omega-3 supplementation significantly lessened joint pain compared to a placebo. This improvement was accompanied by increased joint function, suggesting omega-3s might help people with OA move more easily and comfortably.
Research: Kuszewski JC, Wong RHX, Howe PRC. Fish oil supplementation reduces osteoarthritis-specific pain in older adults with...
Health Impact
Codeine + Aspirin-induced nutrient depletion can lead to a range of health problems
Scurvy & Fragile Blood Vessels
Modern case reports and re-analyses of classic scurvy trials show that vitamin C deficiency causes defective collagen and capillary integrity, with slow recovery of scar strength even after repletion if deficiency is prolonged.
Research: Gandhi M et al. Scurvy: rediscovering a forgotten disease. Clin Case Rep. 2023;11(6):e10296835.; Hujoel PP, Hujoel MLA....
Delayed Wound Healing & Fatigue
Systematic reviews report improved healing of chronic wounds with vitamin C supplementation in deficient or high-need states, supporting the clinical impact of inadequate ascorbate on tissue repair.
Research: Bechara N et al. The role of vitamin C in tissue repair and wound healing: a systematic review. Int Wound J....
B12-Related Megaloblastic Anemia
Clinical reviews identify vitamin B12 deficiency as a common cause of megaloblastic anemia; hematologic abnormalities often improve with replacement, underscoring the hematopoietic consequences of depletion.
Research: Langan RC, Zawistoski KJ. Update on vitamin B12 deficiency. Am Fam Physician. 2017;96(6):384-389.; Green R. Vitamin B12...
B12 Neuropathy & Cognitive Decline
Systematic reviews and observational data show associations between low B12 levels and peripheral neuropathy, myelopathy and cognitive impairment; neurological manifestations may become irreversible if depletion is prolonged.
Research: Badar A et al. Neuropsychiatric disorders associated with vitamin B12 deficiency: an updated review. Cureus....
Side Effects
Common side effects of Codeine + Aspirin, some of which may be related to nutrient depletion
Review
The following are some common side effects of the analgesic drug combination of codeine and aspirin:
1. Nausea and vomiting
2. Dizziness or lightheadedness
3. Drowsiness or sedation
4. Constipation
5. Headache
6. Dry mouth
7. Difficulty urinating
8. Blurred vision
9. Confusion or disorientation
10. Allergic reactions such as rash, itching, hives, swelling of the face and throat, and difficulty breathing
It is important to note that these are not all possible side effects and individuals may experience different reactions. If you experience any severe or persistent side effects, it is important to seek medical attention immediately.
1. Nausea and vomiting
2. Dizziness or lightheadedness
3. Drowsiness or sedation
4. Constipation
5. Headache
6. Dry mouth
7. Difficulty urinating
8. Blurred vision
9. Confusion or disorientation
10. Allergic reactions such as rash, itching, hives, swelling of the face and throat, and difficulty breathing
It is important to note that these are not all possible side effects and individuals may experience different reactions. If you experience any severe or persistent side effects, it is important to seek medical attention immediately.
Get Support
We've developed a formula to replenish the nutrients depleted by Codeine + Aspirin.
Shop Third-Party Supplements
Vitamin B12 Methylcobalamin
by Pure Encapsulations
Pure Encapsulations' Vitamin B12 supplement provides a high-quality, bioavailable form of vitamin B12 to support energy production, neurological function, and overall health.
Strength: 0.2 mg
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Vitamin B12 Methylcobalamin
Expert Research
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Recommended
Vitamin C (Ascorbic Acid)
by Pure Encapsulations
Pure Encapsulations' Vitamin C supplement is a high-quality, hypoallergenic product designed to support immune function, collagen production, and antioxidant protection.
Strength: 200 mcg
Buy now
Vitamin C (Ascorbic Acid)
Expert Research
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Recommended
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