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Clocortolone
Depletes
Prolonged use of Clocortolone can impact 2 essential nutrients.
Calcium
Corticosteroids can lower calcium levels in the body. This is a double threat to bone health because corticosteroids themselves can weaken bones. Calcium is essential for strong bones, and a study showed that supplementing with both calcium and vitamin D3 helped prevent bone loss in people with rheumatoid arthritis taking corticosteroids. Supplementation with calcium should be considered during long term corticosteroid therapy.
Replace with Calcium Citrate (75 mg)
Research: Homik J, Suarez-Almazor ME, Shea B, Cranney A, Wells G, Tugwell P. Calcium and vitamin D for corticosteroid-induced...
Chromium
Research has found that corticosteroids increased chromium excretion in patients after just three days. Chromium is an essential mineral that helps regulate blood sugar levels. This is important because corticosteroids themselves can raise blood sugar, contributing to diabetes. Evidence suggests that chromium supplementation improved fasting blood glucose levels in patients with steroid-induced diabetes.
Replace with Chromium Polynicotinate (200 mcg)
Research: Mohn ES, Kern HJ, Saltzman E, Mitmesser SH, McKay DL. Evidence of Drug-Nutrient Interactions with Chronic Use of Commonly...
Health Impact
Clocortolone-induced nutrient depletion can lead to a range of health problems
Reduced Bone Density & Fractures
Systematic reviews indicate that increasing calcium intake yields only modest BMD gains and limited fracture risk reduction by itself, but combined calcium and vitamin D supplementation has shown benefits in specific high-risk groups such as postmenopausal women with osteoporosis.
Research: Tai V et al. Calcium intake and bone mineral density: systematic review and meta-analysis. BMJ. 2015;351:h4183.; Liu Y et...
Hypocalcemic Spasms & Tetany
Clinical endocrinology sources describe neuromuscular irritability as a classic manifestation of severe hypocalcemia due to inadequate intake, malabsorption or drug-induced changes in calcium metabolism.
Research: Bilezikian JP. Hypocalcemia. J Clin Endocrinol Metab. 2018;103(10):3827-3839.; Khan AA et al. Diagnosis and management of...
Reduced Insulin Sensitivity
A systematic review and meta-analysis of chromium supplementation in type 2 diabetes suggests small improvements in fasting glucose and HbA1c in some trials, but high-quality randomized studies in prediabetes found no clear benefit, indicating that the clinical impact of chromium depletion remains uncertain.
Research: Asbaghi O et al. Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic...
Unfavorable Metabolic Profile
Narrative reviews highlight associations between low chromium and metabolic derangements, yet interventional trials show heterogeneous results, suggesting that any effect of depletion is modest and context-dependent.
Research: Anderson RA. Chromium and insulin resistance. Nutr Res Rev. 2000;13(2):267-286.; Asbaghi O et al. Effects of chromium...
Side Effects
Common side effects of Clocortolone, some of which may be related to nutrient depletion
Review
Common side effects of Clocortolone, an anti-inflammatory steroid medication, may include burning, itching, redness, or irritation at the application site. Other possible side effects can include thinning skin, skin discoloration, acne, stretch marks, and increased hair growth on the treated area.
More serious side effects may include skin infections, allergic reactions, or worsening of skin conditions. Long-term use or excessive use of corticosteroid medications like Clocortolone can also lead to systemic side effects such as weight gain, high blood pressure, muscle weakness, osteoporosis, and adrenal suppression.
It is important to discuss all possible side effects with your healthcare provider before using Clocortolone and to report any concerning symptoms promptly.
More serious side effects may include skin infections, allergic reactions, or worsening of skin conditions. Long-term use or excessive use of corticosteroid medications like Clocortolone can also lead to systemic side effects such as weight gain, high blood pressure, muscle weakness, osteoporosis, and adrenal suppression.
It is important to discuss all possible side effects with your healthcare provider before using Clocortolone and to report any concerning symptoms promptly.
Get Support
We've curated a list of vetted, recommended individual nutrient third-party supplements.
Shop Third-Party Supplements
Calcium Citrate
by Solaray
The Calcium supplement by Solaray is designed to support bone health and overall wellness by providing a high-quality, bioavailable form of calcium.
Strength: 200mg
Buy now
Calcium Citrate
Expert Research
Recommended
Recommended
Chromium Picolinate
by Pure Encapsulations
Pure Encapsulations Chromium supplement is a dietary supplement designed to support healthy glucose metabolism and overall metabolic function, using a highly bioavailable form of chromium.
Strength: 200 mcg
Buy now
Chromium Picolinate
Expert Research
Recommended
Recommended
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