Ciprofibrate

Ciprofibrate is a medication that belongs to a class of drugs known as fibrates. It is used to help lower cholesterol levels in the blood and reduce the risk of heart disease. Ciprofibrate works by increasing the breakdown of fats in the body and decreasing the production of new fats. It is typically prescribed in combination with a low-fat diet and exercise to help manage high cholesterol levels.

Overview Why It Happens Clinical Evidence Replacement

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Ciprofibrate

Ciprofibrate & B12

Suppresses absorption of B12. This medication is commonly used for High Cholesterol

Why Ciprofibrate affects B12

Research demonstrates that fibrates, particularly fenofibrate, are known to increase homocysteine levels. Elevated levels of homocysteine is associated with increased risk of a range of health problems including atherosclerosis, stroke, and neurological diseases, and vitamin Bs including vitamin B12 helps facilitate the breakdown of homocysteine and may be helpful in reducing homocysteine levels.

Clinical Evidence

Dierkes J, Westphal S, Kunstmann S, Banditt P, Lössner A, Luley C. Vitamin supplementation can markedly reduce the homocysteine elevation induced by fenofibrate. Atherosclerosis. 2001 Sep;158(1):161-4. doi: 10.1016/s0021-9150(00)00766-8. PMID: 11500187. Robinson C, Weigly E. Basic Nutrition and Diet Therapy. New York: Macmillan, 1984, 46–54.

Recommended Replacement

Vitamin B12 (Methylcobalamin) — 100 mcg

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