Cimetidine

Cimetidine is a medication that belongs to a class of drugs known as H2 blockers. It is primarily used to reduce the production of stomach acid in conditions such as acid reflux, ulcers, and gastroesophageal reflux disease (GERD). Cimetidine works by blocking the action of histamine on stomach cells, which helps to decrease the amount of acid produced. It is available both over-the-counter and by prescription.

Overview Why It Happens Clinical Evidence Replacement Other Nutrients

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Cimetidine

Cimetidine & Vitamin D

Depletes Vitamin D. This medication is commonly used for Stomach Acid

Why Cimetidine affects Vitamin D

Certain medications can interfere with how your body processes vitamin D. A study found that cimetidine, a medication used to treat heartburn and ulcers, can decrease the activity of an enzyme (25-hydroxylase) crucial for converting vitamin D into its usable form. A specific study found that cimetidine administration lowered this enzyme activity by 22%. Supplementing with vitamin D when utilizing H2 antagonists/blockers such as Cimetidine (Tagamet HB) should be considered.

Clinical Evidence

Odes HS, Fraser GM, Krugliak P, Lamprecht SA, Shany S. Effect of cimetidine on hepatic vitamin D metabolism in humans. Digestion. 1990;46(2):61-4. Bengoa JM, Bolt MJ, Rosenberg IH. Hepatic vitamin D 25-hydroxylase inhibition by cimetidine and isoniazid. J Lab Clin Med. 1984 Oct;104(4):546-52.

Recommended Replacement

Vitamin D3 (Cholcalciferol) (1000 IU) — 25 mcg

Other Nutrients Affected by Cimetidine

Folic Acid — Depletion
Vitamin B12 — Depletion
Zinc — Depletion
Vitamin A — Suppression

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