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Bryhali

Bryhali is a prescription medication containing the active ingredient halobetasol propionate. It is a high-potency corticosteroid that is used topically to treat inflammatory skin conditions such as eczema, psoriasis, and dermatitis. Bryhali helps to reduce inflammation, redness, itching, and swelling associated with these skin conditions. It is available as a foam for application to the affected area of the skin.

Depletion Health Impact Side Effects Recommendation

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Bryhali

Depletes

Prolonged use of Bryhali can impact 2 essential nutrients.

Calcium

Corticosteroids can lower calcium levels in the body. This is a double threat to bone health because corticosteroids themselves can weaken bones. Calcium is essential for strong bones, and a study showed that supplementing with both calcium and vitamin D3 helped prevent bone loss in people with rheumatoid arthritis taking corticosteroids. Supplementation with calcium should be considered during long term corticosteroid therapy.

Replace with Calcium Citrate (75 mg)

Research: Homik J, Suarez-Almazor ME, Shea B, Cranney A, Wells G, Tugwell P. Calcium and vitamin D for corticosteroid-induced...

Chromium

Research has found that corticosteroids increased chromium excretion in patients after just three days. Chromium is an essential mineral that helps regulate blood sugar levels. This is important because corticosteroids themselves can raise blood sugar, contributing to diabetes. Evidence suggests that chromium supplementation improved fasting blood glucose levels in patients with steroid-induced diabetes.

Replace with Chromium Polynicotinate (200 mcg)

Research: Mohn ES, Kern HJ, Saltzman E, Mitmesser SH, McKay DL. Evidence of Drug-Nutrient Interactions with Chronic Use of Commonly...

Health Impact

Bryhali-induced nutrient depletion can lead to a range of health problems

Reduced Bone Density & Fractures

Systematic reviews indicate that increasing calcium intake yields only modest BMD gains and limited fracture risk reduction by itself, but combined calcium and vitamin D supplementation has shown benefits in specific high-risk groups such as postmenopausal women with osteoporosis.

Research: Tai V et al. Calcium intake and bone mineral density: systematic review and meta-analysis. BMJ. 2015;351:h4183.; Liu Y et...

Hypocalcemic Spasms & Tetany

Clinical endocrinology sources describe neuromuscular irritability as a classic manifestation of severe hypocalcemia due to inadequate intake, malabsorption or drug-induced changes in calcium metabolism.

Research: Bilezikian JP. Hypocalcemia. J Clin Endocrinol Metab. 2018;103(10):3827-3839.; Khan AA et al. Diagnosis and management of...

Reduced Insulin Sensitivity

A systematic review and meta-analysis of chromium supplementation in type 2 diabetes suggests small improvements in fasting glucose and HbA1c in some trials, but high-quality randomized studies in prediabetes found no clear benefit, indicating that the clinical impact of chromium depletion remains uncertain.

Research: Asbaghi O et al. Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic...

Unfavorable Metabolic Profile

Narrative reviews highlight associations between low chromium and metabolic derangements, yet interventional trials show heterogeneous results, suggesting that any effect of depletion is modest and context-dependent.

Research: Anderson RA. Chromium and insulin resistance. Nutr Res Rev. 2000;13(2):267-286.; Asbaghi O et al. Effects of chromium...

Side Effects

Common side effects of Bryhali, some of which may be related to nutrient depletion

Review

Common side effects of Bryhali (halobetasol propionate) may include:

1. Skin irritation, such as redness, itching, burning, or stinging at the application site
2. Dry skin
3. Folliculitis (inflammation of hair follicles)
4. Contact dermatitis
5. Acne
6. Hypopigmentation (lightening of the skin)
7. Hypertrichosis (excessive hair growth)
8. Skin atrophy (thinning of the skin)

These are not all possible side effects of Bryhali. Consult with your healthcare provider for more information about the potential risks and benefits of this medication.

Get Support

We've curated a list of vetted, recommended individual nutrient third-party supplements.

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Calcium Citrate

by Solaray

The Calcium supplement by Solaray is designed to support bone health and overall wellness by providing a high-quality, bioavailable form of calcium.

Strength: 200mg

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Calcium Citrate

Expert Research
Recommended

Chromium Picolinate

by Pure Encapsulations

Pure Encapsulations Chromium supplement is a dietary supplement designed to support healthy glucose metabolism and overall metabolic function, using a highly bioavailable form of chromium.