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Amiloride
Depletes
Prolonged use of Amiloride can impact 7 essential nutrients.
Folic Acid
Studies indicate that diuretics including potassium-sparing, can act as folate antagonists, potentially leading to a deficiency. This occurs because some diuretics inhibit the enzyme responsible for utilizing folate (folic acid) in the body. Research suggests a link between long-term diuretic use (over six months) and decreased blood folate levels while also showing a significant increase in damaging homocysteine levels. Folate supplementation during potassium-sparing diuretic therapy should therefore be considered.
Replace with Folate (.2mg as L-5-Methylfolate) (0.34 DFE)
Research: Maron BA, Loscalzo J. Homocysteine. Clin Lab Med. 2006 Sep;26(3):591-609, vi. doi: 10.1016/j.cll.2006.06.008. PMID:...
Also Benefits From:
Grape Seed Extract
Grape Seed Extracts (GSE) are rich in polyphenols, specifically proanthocyanadins, that provide benefits to the cardiovascular system especially in area of inflammation, hypertension and cardiovascular disease. Studies suggest that the consumption of GSE that is rich in proanthocyanadins, helps protect against myocardial injury, helps lower blood pressure, reduce inflammation, decrease the size of carotid plaque and inhibiting dangerous platelet adhesions and aggregation thereby reducing cardiovascular mortality.
Research: Schön C, Allegrini P, Engelhart-Jentzsch K, Riva A, Petrangolini G. Grape Seed Extract Positively Modulates Blood Pressure...
Niacin
Niacin, a form of vitamin B3, offers a potential double benefit for heart health. It can help lower LDL ("bad") cholesterol and triglycerides, while also raising HDL ("good") cholesterol. This favorable cholesterol profile can reduce the risk of heart disease. But niacin's benefits might extend beyond cholesterol. Some studies suggest it may also play a role in lowering blood pressure. Niacin seems to work by causing blood vessels to relax and dilate, which could improve blood flow and potentially reduce strain on the heart, thereby lowering blood pressure.
Research: Digby JE, Ruparelia N, Choudhury RP. Niacin in cardiovascular disease: recent preclinical and clinical developments....
Taurine
Beyond its general health benefits, Taurine shines for its potential to support a healthy heart and blood pressure. This amino acid boasts anti-inflammatory and antioxidant properties, which may help protect against hypertension. Studies suggest it can modulate blood sugar levels, potentially reducing the risk of diabetes and its complications like heart disease. Taurine's overall impact on the cardiovascular system is promising, with some evidence indicating it may be essential for proper heart function and development.
Research: Ahmadian M, Dabidi Roshan V, Ashourpore E. Taurine Supplementation Improves Functional Capacity, Myocardial Oxygen...
Vitamin B12
Vitamin B12 plays a crucial role in cardiovascular health by regulating homocysteine levels. Homocysteine is an amino acid, and high levels in the blood are a risk factor for heart attack and stroke. Vitamin B12 acts as a key player in the homocysteine metabolism process, helping to convert it into other beneficial compounds. By keeping homocysteine in check, Vitamin B12 may help reduce the risk of cardiovascular problems.
Research: Celik SF, Celik E. Subclinical atherosclerosis and impaired cardiac autonomic control in pediatric patients with Vitamin B12...
Vitamin B6
Vitamin B6, a crucial B vitamin, plays a significant role in heart health. It helps regulate homocysteine levels in the blood. High homocysteine is a risk factor for atherosclerosis, the buildup of plaque in arteries that can lead to heart disease. By keeping homocysteine in check, Vitamin B6 may help lower the risk of heart problems. Additionally, some research suggests Vitamin B6 may also play a role in managing hypertension (high blood pressure). While the exact mechanism isn't fully understood, Vitamin B6 deficiency has been linked to an increased risk of hypertension.
Research: Stach K, Stach W, Augoff K. Vitamin B6 in Health and Disease. Nutrients. 2021 Sep 17;13(9):3229. Yuan S, Mason AM, Carter P,...
Vitamin C
Vitamin C (Ascorbic acid) goes beyond just immune system support. This powerful antioxidant combats free radicals and oxidative stress, potentially reducing the risk of various diseases. While most recognized for its role in white blood cell production, research suggests Vitamin C may also benefit heart health and blood pressure. It might help protect against damage caused by free radicals in blood vessels, potentially lowering the risk of cardiovascular disease. Additionally, studies indicate Vitamin C may play a role in lowering blood pressure
Research: Guan Y, Dai P, Wang H. Effects of vitamin C supplementation on essential hypertension: A systematic review and...
Health Impact
Amiloride-induced nutrient depletion can lead to a range of health problems
High Homocysteine & Vascular Risk
Meta-analyses of randomized trials show that folic acid supplementation lowers homocysteine and modestly reduces stroke and overall cardiovascular disease risk in some populations, especially where baseline folate status is low, highlighting the adverse vascular profile of folate deficiency.
Research: Li Y et al. Folic acid supplementation and the risk of cardiovascular diseases: a meta-analysis of randomized controlled...
Folate-Related Megaloblastic Anemia
Hematology and nutrition reviews describe folate deficiency as a classic cause of megaloblastic anemia and mucosal abnormalities, frequently exacerbated by medications that antagonize folate metabolism.
Research: O’Leary F, Samman S. Vitamin B12 in health and disease. Nutrients. 2010;2(3):299-316. (discussion of folate and B12 in...
Side Effects
Common side effects of Amiloride, some of which may be related to nutrient depletion
Review
Like all medications, amiloride can also cause side effects. Some common side effects of amiloride include:
1. Dizziness or lightheadedness
2. Nausea or vomiting
3. Muscle cramps or weakness
4. Increased urination
5. Headache
6. Fatigue or weakness
7. Blurred vision
8. Rash or itching
These side effects are generally mild and may go away on their own as your body adjusts to the medication. However, if you experience any severe or persistent side effects, you should contact your healthcare provider immediately. Additionally, amiloride may also interact with other medications, so it is important to inform your doctor about all the medications you are taking before starting treatment with amiloride.
1. Dizziness or lightheadedness
2. Nausea or vomiting
3. Muscle cramps or weakness
4. Increased urination
5. Headache
6. Fatigue or weakness
7. Blurred vision
8. Rash or itching
These side effects are generally mild and may go away on their own as your body adjusts to the medication. However, if you experience any severe or persistent side effects, you should contact your healthcare provider immediately. Additionally, amiloride may also interact with other medications, so it is important to inform your doctor about all the medications you are taking before starting treatment with amiloride.
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Folate
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