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Aleve PM
Depletes
Prolonged use of Aleve PM can impact 3 essential nutrients.
Folic Acid
Regular use of non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen may decrease your folic acid (folate) levels. This is because NSAIDs can interfere with how your body processes folate. If you take OTC pain relievers regularly, consider folate supplementation to avoid potential deficiencies.
Replace with Folate (.2mg as L-5-Methylfolate) (0.34 DFE)
Research:
Taurine
Recent suggests that damage caused by free radicals in tissues plays a role in stomach ulcers (gastric mucosal lesions) caused by nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen. Based on this, it was investigated whether the amino acid taurine could protect the stomach lining from ibuprofen-induced damage. The study also examined the effects of taurine on the stomach's natural antioxidant defenses, including enzymes like superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX), as well as a molecule called glutathione (GSH). It found that giving taurine orally for three days in a row protected the rats' stomach linings from the ulcers caused by ibuprofen. Additionally, taurine significantly reduced a marker of free radical damage (lipid peroxidation) in the ibuprofen-treated rats.
Replace with Taurine (250 mg)
Research: Balasubramanian T, Somasundaram M, Felix AJ. Taurine prevents Ibuprofen-induced gastric mucosal lesions and influences...
Also Benefits From:
Omega 3
Omega-3 fatty acids offer promise for managing pain associated with osteoarthritis (OA). Research suggests they may work by reducing inflammation, a key contributor to OA pain and stiffness. Studies involving over 2000 patients with OA showed that omega-3 supplementation significantly lessened joint pain compared to a placebo. This improvement was accompanied by increased joint function, suggesting omega-3s might help people with OA move more easily and comfortably.
Research: Kuszewski JC, Wong RHX, Howe PRC. Fish oil supplementation reduces osteoarthritis-specific pain in older adults with...
Health Impact
Aleve PM-induced nutrient depletion can lead to a range of health problems
High Homocysteine & Vascular Risk
Meta-analyses of randomized trials show that folic acid supplementation lowers homocysteine and modestly reduces stroke and overall cardiovascular disease risk in some populations, especially where baseline folate status is low, highlighting the adverse vascular profile of folate deficiency.
Research: Li Y et al. Folic acid supplementation and the risk of cardiovascular diseases: a meta-analysis of randomized controlled...
Folate-Related Megaloblastic Anemia
Hematology and nutrition reviews describe folate deficiency as a classic cause of megaloblastic anemia and mucosal abnormalities, frequently exacerbated by medications that antagonize folate metabolism.
Research: O’Leary F, Samman S. Vitamin B12 in health and disease. Nutrients. 2010;2(3):299-316. (discussion of folate and B12 in...
Higher Blood Pressure & Vascular Strain
Randomized controlled trials in prehypertensive and cardiovascular patients show that taurine supplementation lowers blood pressure and improves vascular function, suggesting that inadequate taurine can impair cardiovascular regulation under stress.
Research: Sun Q et al. Taurine supplementation lowers blood pressure and improves vascular function in prehypertension: randomized,...
Reduced Exercise Tolerance in Heart Failure
Older and recent trials in congestive heart failure report improved left ventricular ejection fraction and functional class with taurine supplementation, implying that higher taurine availability benefits myocardial performance.
Research: Azuma J et al. Double-blind randomized crossover trial of taurine in congestive heart failure. Curr Ther Res Clin Exp....
Side Effects
Common side effects of Aleve PM, some of which may be related to nutrient depletion
Review
Some common side effects of Aleve PM include:
- Upset stomach or stomach pain
- Drowsiness
- Dizziness
- Headache
- Nausea
- Constipation
- Fatigue
- Dry mouth
- Blurred vision
More serious side effects may include allergic reactions, difficulty breathing, swelling of the face, lips, tongue, or throat, chest pain, and signs of stomach bleeding such as bloody or tarry stools. If you experience any of these serious side effects, seek medical attention immediately.
- Upset stomach or stomach pain
- Drowsiness
- Dizziness
- Headache
- Nausea
- Constipation
- Fatigue
- Dry mouth
- Blurred vision
More serious side effects may include allergic reactions, difficulty breathing, swelling of the face, lips, tongue, or throat, chest pain, and signs of stomach bleeding such as bloody or tarry stools. If you experience any of these serious side effects, seek medical attention immediately.
Get Support
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Folate
by Pure Encapsulations
Pure Encapsulations' Folic Acid supplement provides a high-quality, bioavailable form of folic acid to support healthy fetal development, cardiovascular health, and overall cellular function.
Strength: 800 mcg
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Folate
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Taurine
by Pure Encapsulations
The Taurine supplement by Pure Encapsulations is a dietary supplement designed to support cardiovascular health, electrolyte balance, and overall cellular function, using high-quality, hypoallergenic ingredients.
Strength: 500 mg
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Taurine
Expert Research
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